Last data update: May 13, 2024. (Total: 46773 publications since 2009)
Records 1-4 (of 4 Records) |
Query Trace: Govinda V[original query] |
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Malignant Transformation of Hymenolepis nana in a Human Host.
Muehlenbachs A , Bhatnagar J , Agudelo CA , Hidron A , Eberhard ML , Mathison BA , Frace MA , Ito A , Metcalfe MG , Rollin DC , Visvesvara GS , Pham CD , Jones TL , Greer PW , Velez Hoyos A , Olson PD , Diazgranados LR , Zaki SR . N Engl J Med 2015 373 (19) 1845-52 Neoplasms occur naturally in invertebrates but are not known to develop in tapeworms. We observed nests of monomorphic, undifferentiated cells in samples from lymph-node and lung biopsies in a man infected with the human immunodeficiency virus (HIV). The morphologic features and invasive behavior of the cells were characteristic of cancer, but their small size suggested a nonhuman origin. A polymerase-chain-reaction (PCR) assay targeting eukaryotes identified Hymenolepis nana DNA. Although the cells were unrecognizable as tapeworm tissue, immunohistochemical staining and probe hybridization labeled the cells in situ. Comparative deep sequencing identified H. nana structural genomic variants that are compatible with mutations described in cancer. Invasion of human tissue by abnormal, proliferating, genetically altered tapeworm cells is a novel disease mechanism that links infection and cancer. |
Identification of Giardia duodenalis and Enterocytozoon bieneusi in an epizoological investigation of a laboratory colony of prairie dogs, Cynomys ludovicianus.
Roellig DM , Salzer JS , Carroll DS , Ritter JM , Drew C , Gallardo-Romero N , Keckler MS , Langham G , Hutson CL , Karem KL , Gillespie TR , Visvesvara GS , Metcalfe MG , Damon IK , Xiao L . Vet Parasitol 2015 210 91-7 Since 2005, black-tailed prairie dogs (Cynomys ludovicianus) have been collected for use as research animals from field sites in Kansas, Colorado, and Texas. In January of 2012, Giardia trophozoites were identified by histology, thin-section electron microscopy, and immunofluorescent staining in the lumen of the small intestine and colon of a prairie dog euthanized because of extreme weight loss. With giardiasis suspected as the cause of weight loss, a survey of Giardia duodenalis in the laboratory colony of prairie dogs was initiated. Direct immunofluorescent testing of feces revealed active shedding of Giardia cysts in 40% (n=60) of animals held in the vivarium. All tested fecal samples (n=29) from animals in another holding facility where the index case originated were PCR positive for G. duodenalis with assemblages A and B identified from sequencing triosephosphate isomerase (tpi), glutamate dehydrogenase (gdh), and beta-giardin (bg) genes. Both assemblages are considered zoonotic, thus the parasites in prairie dogs are potential human pathogens and indicate prairie dogs as a possible wildlife reservoir or the victims of pathogen spill-over. Molecular testing for other protozoan gastrointestinal parasites revealed no Cryptosporidium infections but identified a host-adapted Enterocytozoon bieneusi genotype group. |
Transplant patient with skin nodules
Kandukuri S , Morgan M , Zakowski P , Govinda V , Falk J , Roy S , Chaux G , Ghandehari S , Wu J . Am J Dermatopathol 2015 37 (3) 254-6 Answer: Acanthanmoeba spp. Hematoxylin and eosin (H/E)-stained tissue sections revealed edematous mucose with evidence of moderate acute and chronic inflammation and confluent areas of necrosis. Within the necrotic tissue were scattered double-walled wrinkled cystic structures and trophozoites were identified within a vessel wall, indicitave of angioinvasion. Gomori Methenamine silver (GMS) and periodic acid Schiff stains highlighted the cysts and trophozoites. |
Evaluation of anti-vibration effectiveness of glove materials using an animal model
Xu XS , Riley DA , Persson M , Welcome DE , Krajnak K , Wu JZ , Govinda Raju SR , Dong RG . Biomed Mater Eng 2011 21 (4) 193-211 Gloves with anti-vibration features are increasingly used to reduce impact vibrations or shocks transmitted to the hands of power tool operators. Selection and evaluation of the glove materials are important steps in the designs of such gloves. In the current study, we proposed an approach to objectively evaluate the effectiveness of the glove materials using a rat-tail impact model. As a critical part of a systematic investigation, we examined the vibration reduction characteristics of typical resilient glove materials (air bladders and viscoelastic gels) and the impact vibrations transmitted to the rat tail. A special test platform that mimics impact tool vibrations was constructed and used in the experiment. A scanning laser vibrometer was used to measure the vibration at points across the platform surface under several different test conditions. The peak acceleration was found to be greatly attenuated by the glove materials, especially by using strips from a gel-filled glove. The rat tail was found to effectively absorb the high-frequency vibration. However, the glove materials and the rat tail did not reduce the frequency-weighted acceleration. The implications of the experimental results are discussed. |
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